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IntroductionThe conversion of epithelial to mesenc

 
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PostPosted: Sat 14:24, 28 Dec 2013    Post subject: IntroductionThe conversion of epithelial to mesenc

IntroductionThe conversion of epithelial to mesenchymal cells, named EMT, has important functions in cell differentiation and organogenesis. Furthermore, it plays a part in tissue repair and also to disease, with adjustments in EMT associated with tissue fibrosis, immunosuppression and carcinogenesis (Thiery et al, 2009). EMT involves striking cellular changes, including loss in cell adhesion and polarity and gain of migratory and even invasive properties. Wnt and TGF initiate, amplify and modulate EMT, inducing gene expression changes that induce the cell's phenotypic transitions (Thiery and Sleeman, 2006; Thiery et al, 2009). Thus, [url=http://www.aagstucchi.it/aagstucchi.asp]Moncler Outlet Italia[/url] activation of transcriptional regulators similar to Snail and [url=http://www.villanurbs.com/supra.asp]Supra en España[/url] transcriptional changes such as downregulation of Ecadherin or upregulation of Vimentin are classical landmarks of EMT. Picture emerging from your work of Warzecha et al (2010) with [url=http://www.villanurbs.com/supra.asp]Supra España[/url] this issue of The EMBO Journal and also a previous report through the Carstens' group (Warzecha et al, 2009) is always that alternative splicing has an additional layer of gene regulation that includes [url=http://www.promovec.dk/promovec.asp]canada goose jakke[/url] to shape the EMT process.
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